Porifera
There are no endocrine glands in sponges. But they have exocrine glands that release a secretion to the surface. Studies over the last two decades have revealed that sponges produce a surprisingly broad spectrum of biotoxins, some of which are quite potent. A few, such as those of Tedania and neofibularia can cause painful skin rashes in humans. Not only are those chemicals used to deter predators they are also helpful to prevent infection by microbes and to compete for space with other sessile invertebrates such as ascidians, corals and even other sponges.